Article
NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia.
Pediatric blood & cancer - 1 Oct 2004
Sirma Sema, Agaoglu Leyla, Yildiz Inci, Cayli Dilara, Horgusluoglu Emrin, Anak Sema, Yuksel Lebriz, Unuvar Aysegul, Celkan Tiraje, Apak Hilmi, Karakas Zeynep, Devecioglu Omer, Ozbek Ugur
Abstract excerpt
BACKGROUND: NAD(P)H:quinone oxidoreductase1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Exposure to benzene metabolites increases the risk of hematotoxicity and leukemia. NQO1 enzyme activity protects the cells against...
Topics
- Acute Disease
- Adolescent
- Child
- Child, Preschool
- Female
- Genotype
- Humans
- Infant
- Leukemia, Myeloid
- Male
- NAD(P)H Dehydrogenase (Quinone)
- Polymerase Chain Reaction