Article
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.
Blood - 15 Dec 2002
Smith Martyn T, Wang Yunxia, Skibola Christine F, Slater Diana J, Lo Nigro Luca, Nowell Peter C, Lange Beverly J, Felix Carolyn A
Abstract excerpt
An inactivating polymorphism at position 609 in the NAD(P)H:quinone oxidoreductase 1 gene (NQO1 C609T) is associated with an increased risk of adult leukemia. A small British study suggested that NQO1 C609T was associated with an increased risk of infant leukemias with MLL translocations, especially infant acute lymphoblastic leukemia (ALL) with t(4;11). We explored NQO1 C609T as a genetic risk factor in 39...
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