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Article

NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.

American journal of epidemiology - 1 Dec 2008

Guha Neela, Chang Jeffrey S, Chokkalingam Anand P, Wiemels Joseph L, Smith Martyn T, Buffler Patricia A

Abstract excerpt

Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the detoxification of quinone carcinogens, have been associated with childhood leukemia in some studies, although the observed direction and magnitude of effects have been inconsistent. Therefore, the authors systematically reviewed all published reports describing the effect of NQO1 in de novo childhood leukemia and conducted a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18945694
DOI: 10.1093/aje/kwn246
PMCID: PMC2727266

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.PMID 18945694Read ↗

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.Semantic proximity Read ↗

Increased risk for acute lymphoblastic leukemia in children with cytochrome P450A1 (CYP1A1)- and NAD(P)H:quinone oxidoreductase 1 (NQO1)-inherited gene variants.Semantic proximity Read ↗

Novel insights into etiologies of leukemia: a HuGE review and meta-analysis of CYP1A1 polymorphisms and leukemia risk.Semantic proximity Read ↗

Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.Semantic proximity Read ↗

A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.Semantic proximity Read ↗

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