Article
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.
American journal of epidemiology - 1 Dec 2008
Guha Neela, Chang Jeffrey S, Chokkalingam Anand P, Wiemels Joseph L, Smith Martyn T, Buffler Patricia A
Abstract excerpt
Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the detoxification of quinone carcinogens, have been associated with childhood leukemia in some studies, although the observed direction and magnitude of effects have been inconsistent. Therefore, the authors systematically...
Topics
- Alleles
- California
- Case-Control Studies
- Child
- Confidence Intervals
- Histone-Lysine N-Methyltransferase
- Humans
- Leukemia, Myeloid, Acute
- Myeloid-Lymphoid Leukemia Protein
- NAD(P)H Dehydrogenase (Quinone)
- Odds Ratio
- Polymorphism, Genetic
- Precursor Cell Lymphoblastic Leukemia-Lymphoma