Article
Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malignancies.
Collegium antropologicum - 1 Jun 2011
Lozić Bernarda, Primorac Dragan, Glavinić Robert, Samija Radenka Kuzmanić, Zemunik Tatijana
Abstract excerpt
In this study we analyzed the effect of polymorphic variation of NAD(P)H: quinone oxidoreductase1 (NQO1) gene that encode enzyme which detoxifies harmful quinines and protect hematopoietic stem cells against oxidative stress. C609T polymorphism of NQO1 gene leads to loss of enzyme activity, which may be a risk factor in the etiology of specific types of hematopoietic malignancies. We analyzed C609T polymorphism...
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