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Article

Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.

Blood - 1 Mar 2001

Smith M T, Wang Y, Kane E, Rollinson S, Wiemels J L, Roman E, Roddam P, Cartwright R, Morgan G

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress. A cysteine-to-threonine (C --> T) substitution polymorphism at nucleotide 609 of the NQO1 complementary DNA (NQO1 C609T) results in a lowering of NQO1 activity. Individuals homozygous for this mutation have no NQO1 activity, and heterozygotes have low to intermediate activity compared with people with wild...

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Source

Identifiers

PMID: 11222389
DOI: 10.1182/blood.v97.5.1422

Genes

NQO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.PMID 11222389Read ↗

Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.Semantic proximity Read ↗

A meta-analysis of the association between NQO1 C609T variation and acute myeloid leukemia risk.Semantic proximity Read ↗

Association between NQO1 C609T polymorphism and acute lymphoblastic leukemia risk: evidence from an updated meta-analysis based on 17 case-control studies.Semantic proximity Read ↗

Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malignancies.Semantic proximity Read ↗

NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia.Semantic proximity Read ↗

NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.Semantic proximity Read ↗

Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.Semantic proximity Read ↗

NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution.Semantic proximity Read ↗

Effects of the NQO1 609C>T polymorphism on leukemia susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms.Semantic proximity Read ↗

High frequency of NAD(P)H:quinone oxidoreductase 1 (NQO1) C(609)T germline polymorphism in MDS/AML with trisomy 8.Semantic proximity Read ↗

Genetic polymorphism of NAD(P)H:quinone oxidoreductase is associated with an increased risk of infant acute lymphoblastic leukemia without MLL gene rearrangements.Semantic proximity Read ↗

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