Article
NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms.
Haematologica - 1 Dec 2004
Kracht Thorben, Schrappe Martin, Strehl Sabine, Reiter Alfred, Elsner Holger-Andreas, Trka Jan, Cario Gunnar, Viehmann Susanne, Harbott Jochen, Borkhardt Arndt, Metzler Markus, Langer Thorsten, Repp Reinald, Marschalek Rolf, Welte Karl, Haas Oskar A, Stanulla Martin
Abstract excerpt
BACKGROUND AND OBJECTIVES: NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T) have intermediate activity and homozygotes for the variant allele (T/T) are deficient in NQO1...
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