NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution.

doi:10.1007/s10552-012-0060-5

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Article

NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution.

Cancer causes & control : CCC - 1 Nov 2012

de Aguiar Gonçalves Bruno Alves, Vasconcelos Gisele M, Thuler Luiz Claudio Santos, Andrade Camilla, Faro Alessandra, Pombo-de-Oliveira Maria S, Emerenciano Mariana, de Camargo Beatriz, Bernstain Luna, Neves Cynthia Curvello, Agareno Jozina Maria de Andrade, de Carvalho Lilian Maria Burlacchini, Araújo Flávia Nogueira Serafim, de Brito Nilma Pimentel, Magalhães Isis Q, Cordoba José Carlos, Pimenta Flávia, Gadelha Andreia, Cartaxo Eloísa, Basegio Rosania Maria, Mnayarji Atalla, Souza Marcelo S, Arencibia Alejandro, Melaragno Renato, Cóser Virgínia Maria, Lafayete Thereza Christina, Koifman Sergio

Abstract excerpt

PURPOSE: The risk of developing childhood leukemia has been associated with gene polymorphisms that decrease the activity of detoxifying metabolic enzymes and enzymes involved in systemic oxidative stress. We investigated the NQO1 and PON1 polymorphisms for associations with susceptibility to childhood leukemia. METHODS: Samples from 1,027 Brazilian children (519 acute lymphoblastic leukemia, ALL; 107 acute...

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Identifiers

PMID: 22976839
DOI: 10.1007/s10552-012-0060-5

Genes

PON1
NQO1
ETV6
RUNX1

Variants

rs1800566
rs1800566
rs1800566
rs662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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