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Article

[Semi-automated quantitative method for detecting the loss of heterozygosity at the long arm of chromosome 4 in hepatocellular carcinoma].

Gastroenterologie clinique et biologique - 1 Nov 1999

Bluteau O, Legoix P, Bayer J, Bioulac-Sage P, Fléjou J F, Capron F, Monges G, Brechot C, Thomas G, Laurent-Puig P, Zucman-Rossi J

Abstract excerpt

OBJECTIVES: Chromosomal deletions are the most frequent genetic alterations observed in hepatocellular carcinoma. Loss of heterozygosity on chromosome 4q has been observed in 40% of hepatocellular carcinomas suggesting the presence of a tumor suppressor gene which has not yet been identified. METHODOLOGY: We developed a semi-automated quantitative genotyping method which allowed us to characterize 119...

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PMID: 10617833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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