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Article

Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.

British journal of cancer - 1 Apr 1999

Rashid A, Wang J S, Qian G S, Lu B X, Hamilton S R, Groopman J D

Abstract excerpt

The major risk factors for hepatocellular carcinomas (HCC) in high incidence areas include infection with hepatitis B and C viruses (HBV, HCV) and exposure to aflatoxin. Genetic alterations in 24 liver resection specimens from Shanghai and Qidong were studied. Hepatitis B virus was integrated in all patient samples, and a null phenotype for the GSTM1 enzyme was present in 63% of patients. Alteration of p53 was...

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Source

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Identifiers

PMID: 10389978
DOI: 10.1038/sj.bjc.6690321
PMCID: PMC2362990

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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