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Article

Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma.

Genes, chromosomes & cancer - 1 Jul 2010

Arai Yasuhito, Honda Shohei, Haruta Masayuki, Kasai Fumio, Fujiwara Yuiko, Ohshima Junjiro, Sasaki Fumiaki, Nakagawara Akira, Horie Hiroshi, Yamaoka Hiroyuki, Hiyama Eiso, Kaneko Yasuhiko

Abstract excerpt

In a single-nucleotide polymorphism array-based analysis of 56 hepatoblastoma (HB) tumors, allelic imbalances were detected in 37 tumors (66%). Chromosome gains were found in 1q (28 tumors), 2q (24), 6p (8), 8q (8), 17q (6), and 20pq (10), and losses in 1p (6), 4q (9), and 16q (4). Fine mapping delineated the shortest overlapping region (SOR) of gains at 1q32.1 (1.3 Mb) and 2q24.2-q24.3 (4.8 Mb), and losses at...

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Identifiers

PMID: 20461752
DOI: 10.1002/gcc.20770

Genes

MDM4
ANXA10
HTATIP2
IGF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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