Article
REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.
DNA repair - 28 Sept 2005
Poltoratsky Vladimir, Horton Julie K, Prasad Rajendra, Wilson Samuel H
Abstract excerpt
The DNA polymerase beta (Pol beta) null background renders mouse embryonic fibroblast (MEF) cells base excision repair deficient and hyper-mutagenic upon treatment with the monofunctional alkylating agent, methyl methanesulfonate (MMS). This effect involves an increase in all types of base substitutions, with a modest predominance of G to A transitions. In the present study, we examined the hypothesis that the...
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