Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGFR and EGFRvIII expression in primary breast cancer and cell lines.

Breast cancer research and treatment - 1 Sept 2004

Rae James M, Scheys Joshua O, Clark Kim M, Chadwick Robert B, Kiefer Michael C, Lippman Marc E

Abstract excerpt

EGFRvIII is a constitutively activated truncated variant of the epidermal growth factor receptor (EGFR) which has been shown to increase tumorgenicity. There are conflicting reports on the extent of EGFRvIII expression in tissues which may in part stem from the use of different assay methodologies. We investigated the expression of both EGFRvIII and wild-type EGFR (EGFRwt) in cell lines and primary breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to EGFR gene

Share to Phenotype

Share to Polymerase Chain Reaction

Share to RNA, Messenger

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 15377854
DOI: 10.1023/B:BREA.0000041585.26734.f9

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGFR and EGFRvIII expression in primary breast cancer and cell lines.PMID 15377854Read ↗

Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysisSemantic proximity Read ↗

Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma.Semantic proximity Read ↗

Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas.Semantic proximity Read ↗

EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer.Semantic proximity Read ↗

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma SamplesSemantic proximity Read ↗

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.Semantic proximity Read ↗

The epidermal growth factor receptor (EGFR / HER-1) gatekeeper mutation T790M is present in European patients with early breast cancer.Semantic proximity Read ↗

Analysis of the epidermal growth factor receptor specific transcriptome: effect of receptor expression level and an activating mutation.Semantic proximity Read ↗

EGFR-activating mutations are not present in breast tumors of Japanese patients.Semantic proximity Read ↗

Mutant epidermal growth factor receptor in benign, borderline, and malignant ovarian tumors.Semantic proximity Read ↗

Head and neck squamous cell carcinomas do not express EGFRvIII.Semantic proximity Read ↗

Mutations Within the Kinase Domain and Truncations of the Epidermal Growth Factor Receptor Are Rare Events in Bladder Cancer: Implications for TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.