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Article

The epidermal growth factor receptor (EGFR / HER-1) gatekeeper mutation T790M is present in European patients with early breast cancer.

PloS one - 1 Jan 2015

Bemanian Vahid, Sauer Torill, Touma Joel, Lindstedt Bjørn Arne, Chen Ying, Ødegård Hilde Presterud, Vetvik Katja Marjaana, Bukholm Ida Rashida, Geisler Jürgen

Abstract excerpt

The epidermal growth factor receptor (EGFR) is one of the major oncogenes identified in a variety of human malignancies including breast cancer (BC). EGFR-mutations have been studied in lung cancer for some years and are established as important markers in guiding therapy with tyrosine kinase inhibitors (TKIs). In contrast, EGFR-mutations have been reported to be rare if not absent in human BC, although recent...

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Identifiers

PMID: 26267891
DOI: 10.1371/journal.pone.0134398
PMCID: PMC4534377

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The epidermal growth factor receptor (EGFR / HER-1) gatekeeper mutation T790M is present in European patients with early breast cancer.PMID 26267891Read ↗

Lack of EGFR-activating mutations in European patients with triple-negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles.Semantic proximity Read ↗

The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain.Semantic proximity Read ↗

EGFR and EGFRvIII expression in primary breast cancer and cell lines.Semantic proximity Read ↗

EGFR-activating mutations are not present in breast tumors of Japanese patients.Semantic proximity Read ↗

The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers.Semantic proximity Read ↗

Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patientsSemantic proximity Read ↗

Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.Semantic proximity Read ↗

Absence of evidence for epidermal growth factor receptor and human homolog of the Kirsten rat sarcoma-2 virus oncogene mutations in breast cancer.Semantic proximity Read ↗

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma.Semantic proximity Read ↗

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