Article
Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma.
Cancer research - 15 May 2012
Del Vecchio Catherine A, Jensen Kristin C, Nitta Ryan T, Shain A Hunter, Giacomini Craig P, Wong Albert J
Abstract excerpt
EGFRvIII is a tumor-specific variant of the epidermal growth factor receptor (EGFR). Although EGFRvIII is most commonly found in glioblastoma, its expression in other tumor types remains controversial. In this study, we investigated EGFRvIII expression and amplification in primary breast carcinoma. Our analyses confirmed the presence of EGFRvIII, but in the absence of amplification or rearrangement of the EGFR...
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