Article
Head and neck squamous cell carcinomas do not express EGFRvIII.
International journal of radiation oncology, biology, physics - 1 Oct 2014
Melchers Lieuwe J, Clausen Martijn J A M, Mastik Mirjam F, Slagter-Menkema Lorian, Langendijk Johannes A, van der Laan Bernard F A M, van der Wal Jacqueline E, van der Vegt Bert, Roodenburg Jan L N, Schuuring Ed
Abstract excerpt
PURPOSE: To assess the prevalence of EGFRvIII, a specific variant of EGFR (epidermal growth factor receptor), in 3 well-defined cohorts of head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Immunohistochemistry for the specific detection of EGFRvIII using the L8A4 antibody was optimized on formalin-fixed, paraffin-embedded tissue using glioblastoma tissue. It was compared with EGFR and EGFRvIII...
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