Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Oct 2004

Hayes A, Green E K, Pritchard A, Harris J M, Zhang Y, Lambert J C, Chartier-Harlin M C, Pickering-Brown S M, Lendon C L, Mann D M A

Abstract excerpt

OBJECTIVE: To investigate the impact of possession of the -889 C/T polymorphism of the interleukin 1A gene (IL-1A) and the -511 C/T polymorphism of the interleukin 1B gene (IL-1B) on the extent of neuroinflammation in the brain in Alzheimer's disease (AD), as demonstrated by the degree of microglial cell activity associated with each IL-1A and IL-1B genotype. METHOD: Microglial cell activity within the frontal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Autopsy

Share to Cell Division

Share to Interleukin-1

Share to Microglia

Source

Open in PubMed Open full text

Identifiers

PMID: 15377701
DOI: 10.1136/jnnp.2003.030866
PMCID: PMC1738777

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease.PMID 15377701Read ↗

Association of IL-1β, IL-1α and IL-10 single nucleotide polymorphisms with Mini-Mental State Examination and event-related potentialsSemantic proximity Read ↗

Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism.Semantic proximity Read ↗

The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk.Semantic proximity Read ↗

Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease.Semantic proximity Read ↗

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Semantic proximity Read ↗

Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.Semantic proximity Read ↗

Microglial Activation in Alzheimer Disease: Association with APOE GenotypeSemantic proximity Read ↗

IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology.Semantic proximity Read ↗

Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?Semantic proximity Read ↗

Genetic analysis of interleukin-1A C(-889)T polymorphism with Alzheimer disease.Semantic proximity Read ↗

No evidence for association of the monocyte chemoattractant protein-1 (-2518) gene polymorphism and Alzheimer's disease.Semantic proximity Read ↗

Association of interleukin-1 gene polymorphisms with Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.