Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism.

Annals of neurology - 1 Mar 2000

Grimaldi L M, Casadei V M, Ferri C, Veglia F, Licastro F, Annoni G, Biunno I, De Bellis G, Sorbi S, Mariani C, Canal N, Griffin W S, Franceschi M

Abstract excerpt

Overexpression of the pluripotent cytokine interleukin-1 (IL-1) by microglial cells correlates with formation of neuritic beta-amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms in the genes coding for the IL-1alpha, IL-1beta, and IL-1 receptor antagonist cytokines, and tested their association with the occurrence and age at onset of sporadic AD. We found a strong association between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Alzheimer Disease

Share to Genotype

Share to Interleukin-1

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 10716256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism.PMID 10716256Read ↗

Association between the interleukin-1alpha gene and Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.Semantic proximity Read ↗

The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk.Semantic proximity Read ↗

Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease.Semantic proximity Read ↗

Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease.Semantic proximity Read ↗

Association of interleukin-1 gene polymorphisms with Alzheimer's disease.Semantic proximity Read ↗

Interleukin-1 and the immunogenetics of Alzheimer disease.Semantic proximity Read ↗

Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms.Semantic proximity Read ↗

No evidence for association of the monocyte chemoattractant protein-1 (-2518) gene polymorphism and Alzheimer's disease.Semantic proximity Read ↗

Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study.Semantic proximity Read ↗

A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease.Semantic proximity Read ↗

Association of interleukin-I beta and receptor antagonist gene polymorphisms with late onset Alzheimer's disease in Taiwan Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.