GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

doi:10.1093/brain/awv231

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Article

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

Brain : a journal of neurology - 1 Oct 2015

Ramanan Vijay K, Risacher Shannon L, Nho Kwangsik, Kim Sungeun, Shen Li, McDonald Brenna C, Yoder Karmen K, Hutchins Gary D, West John D, Tallman Eileen F, Gao Sujuan, Foroud Tatiana M, Farlow Martin R, De Jager Philip L, Bennett David A, Aisen Paul S, Petersen Ronald C, Jack Clifford R, Toga Arthur W, Green Robert C, Jagust William J, Weiner Michael W, Saykin Andrew J

Abstract excerpt

Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify genes influencing Alzheimer's disease pathogenesis, we performed a genome-wide association study of longitudinal change in brain amyloid burden measured by (18)F-florbetapir PET. A novel association with higher rates of amyloid accumulation independent from APOE (apolipoprotein E) ε4 status was identified in IL1RAP...

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PMID: 26268530
DOI: 10.1093/brain/awv231
PMCID: PMC4671479

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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