Article
Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?
Neurology - 28 May 2002
Green E K, Harris J M, Lemmon H, Lambert J C, Chartier-Harlin M C, St Clair D, Mann D M A, Iwatsubo T, Lendon C L
Abstract excerpt
Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact...
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