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Article

Association of interleukin-1 gene polymorphisms with Alzheimer's disease.

Annals of neurology - 1 Mar 2000

Nicoll J A, Mrak R E, Graham D I, Stewart J, Wilcock G, MacGowan S, Esiri M M, Murray L S, Dewar D, Love S, Moss T, Griffin W S

Abstract excerpt

Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred...

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Identifiers

PMID: 10716257
PMCID: PMC3833599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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