Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression.

The Journal of pathology - 1 Oct 2004

Gonzalez Michael A, Tachibana Kiku-E K, Chin Suet-Feung, Callagy Grace, Madine Mark A, Vowler Sarah L, Pinder Sarah E, Laskey Ronald A, Coleman Nicholas

Abstract excerpt

Geminin inhibits DNA replication by preventing Cdt1 from loading minichromosome maintenance (MCM) proteins onto DNA. The present study has investigated whether the frequency of geminin expression predicts clinical outcome in breast cancer. Immunohistochemistry was used first to examine geminin expression in normal and malignant breast tissue (n = 67). Correlations with cell-cycle parameters, pathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Gene Amplification

Share to In Situ Hybridization, Fluorescence

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Oligonucleotide Array Sequence Analysis

Source

Identifiers

PMID: 15376260
DOI: 10.1002/path.1625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression.PMID 15376260Read ↗

Immunohistochemical expression of geminin in colorectal cancer: Implication of prognostic significanceSemantic proximity Read ↗

Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer.Semantic proximity Read ↗

DNA replication licensing and cell cycle kinetics of normal and neoplastic breast.Semantic proximity Read ↗

Geminin is essential for the development of preimplantation mouse embryosSemantic proximity Read ↗

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read ↗

Selective Killing of Cancer Cells by Suppression of Geminin ActivitySemantic proximity Read ↗

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Semantic proximity Read ↗

Minichromosome maintenance‐7 and geminin are reliable prognostic markers in patients with oral squamous cell carcinoma: immunohistochemical studySemantic proximity Read ↗

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.Semantic proximity Read ↗

Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.Semantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.