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Article

Immunohistochemical expression of geminin in colorectal cancer: Implication of prognostic significance

6 Apr 2009

Abstract excerpt

DNA should be duplicated precisely once per cell cycle to maintain genome integrity. After DNA replication, geminin binding to Cdt1 inhibits uploading of the minichromosome maintenance (MCM) complex as DNA helicase onto chromatin and prevents DNA re-replication in the same cell cycle. Expression of geminin indicates poor prognosis in some malignancies, such as breast and renal cell carcinoma. We evaluated the...

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PMID: 19360293
DOI: 10.3892/or_00000340

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Immunohistochemical expression of geminin in colorectal cancer: Implication of prognostic significancePMID 19360293Read ↗

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Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M CheckpointSemantic proximity Read ↗

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Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

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