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Article

DNA replication licensing and cell cycle kinetics of normal and neoplastic breast.

British journal of cancer - 28 Nov 2005

Shetty A, Loddo M, Fanshawe T, Prevost A T, Sainsbury R, Williams G H, Stoeber K

Abstract excerpt

Mcm2-7 (MCM) proteins are part of the origin licensing machinery that regulates initiation of DNA replication. Geminin is a licensing repressor and prevents reinitiation of DNA replication during S-G2-M phase by blocking reloading of Mcm2-7 at replication origins. Here, we have analysed these replication licensing factors (RLFs) to determine whether the pathway becomes deregulated during mammary carcinogenesis,...

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Identifiers

PMID: 16278669
DOI: 10.1038/sj.bjc.6602829
PMCID: PMC2361513

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