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Article

Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.

American journal of physiology. Endocrinology and metabolism - 1 Sept 2006

Yu Haiyan, Hirshman Michael F, Fujii Nobuharu, Pomerleau Jason M, Peter Lauren E, Goodyear Laurie J

Abstract excerpt

AMP-activated protein kinase (AMPK) is a heterotrimeric complex that works as an energy sensor to integrate nutritional and hormonal signals. The naturally occurring R225Q mutation in the gamma3-subunit in pigs is associated with abnormally high glycogen content in skeletal muscle. Because skeletal muscle accounts for most of the body's glucose uptake, and gamma3 is specifically expressed in skeletal muscle, it...

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Identifiers

PMID: 16638825
DOI: 10.1152/ajpendo.00073.2006

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Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation.PMID 16638825Read ↗

Cloning and characterization of mouse 5'-AMP-activated protein kinase gamma3 subunit.Semantic proximity Read ↗

Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle.Semantic proximity Read ↗

Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation.Semantic proximity Read ↗

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.Semantic proximity Read ↗

Role of AMP--activated protein kinase in the control of glucose homeostasis.Semantic proximity Read ↗

The human AMPKγ3 R225W mutation does neither enhance basal AMPKγ3-associated activity nor glycogen in human or mouse skeletal muscleSemantic proximity Read ↗

The human AMPKγ3 R225W mutation negatively impacts site-1 nucleotide binding and does not enhance basal AMPKγ3-associated activity nor glycogen production in human or mouse skeletal muscle.Semantic proximity Read ↗

The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.Semantic proximity Read ↗

Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.Semantic proximity Read ↗

5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics.Semantic proximity Read ↗

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UDP-glucose pyrophosphorylase is upregulated in carriers of the porcine RN- mutation in the AMP-activated protein kinase.Semantic proximity Read ↗

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