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Article

Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies.

Pharmacogenetics - 1 Jun 1997

Schulz W A, Krummeck A, Rösinger I, Eickelmann P, Neuhaus C, Ebert T, Schmitz-Dräger B J, Sies H

Abstract excerpt

The NQO1 locus on chromosome 16q2.2 encodes NAD(P)H:quinone oxidoreductase, an enzyme implicated in detoxication and protection against redox cycling. Two alleles have been identified in the human population, the rarer one, termed the null-allele, coding for a nonfunctional enzyme. Since lack of NQOR activity has been suggested to increase susceptibility to certain cancers, the distribution of the two alleles was...

Topics

Alleles
Carcinoma
Carcinoma, Renal Cell
Female
Gene Frequency
Genotype
Humans
Male
NAD(P)H Dehydrogenase (Quinone)
Odds Ratio
Urologic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9241663
DOI: 10.1097/00008571-199706000-00008

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9241663-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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