Article
An association between NQO1 genetic polymorphism and risk of bladder cancer.
Mutation research - 20 Apr 2003
Park Seun-Ja, Zhao Hua, Spitz Margaret R, Grossman H Barton, Wu Xifeng
Abstract excerpt
NAD(P)H:quinone oxidoreductase (NQO1) is a detoxification enzyme that plays a critical role in protecting cells against chemically induced oxidative stress, cytotoxicity, mutagenicity, and carcinogenicity. NQO1 protects cells from oxidative damage by preventing the generation of reactive oxygen species and reducing certain environmental carcinogens, such as nitroaromatic compounds, heterocyclic amines, and...
Topics
- Aged
- Case-Control Studies
- Ethnicity
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Odds Ratio
- Polymorphism, Genetic