Article
GSTP1 and GSTO1 single nucleotide polymorphisms and the response of bladder cancer patients to intravesical chemotherapy.
Scientific reports - 10 Sept 2015
Deng Xiaheng, Yang Xiao, Cheng Yidong, Liu Xuzhong, Li Xiao, Zhao Ruizhe, Qin Chao, Lu Qiang, Yin Changjun
Abstract excerpt
SNPs may restrict cell detoxification activity and be a potential risk factor for cancer chemosensitivity. We evaluated the predictive value of these polymorphisms on the sensitivity of bladder cancer patients to epirubicin and mitomycin chemotherapy instillation as well as their toxicities. SNPs were analyzed by TaqMan genotyping assays in 130 patients treated with epirubicin and 114 patients treated with...
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