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Article

Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia.

Clinical pharmacology and therapeutics - 1 Sept 2004

Plasschaert Sabine L A, Groninger Ellis, Boezen Marike, Kema Ido, de Vries Elisabeth G E, Uges Donald, Veerman Anjo J P, Kamps Willem A, Vellenga Edo, de Graaf Siebold S, de Bont Eveline S J M

Abstract excerpt

OBJECTIVE: Our objective was to investigate the effect of single nucleotide polymorphisms (SNPs) in the P-glycoprotein MDR1 gene on vincristine pharmacokinetics and side effects in childhood acute lymphoblastic leukemia. METHODS: From 52 of 70 children who participated in a previous study on vincristine pharmacokinetics, patient material was available for investigation of the MDR1 genetic variants. The SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15371983
DOI: 10.1016/j.clpt.2004.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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