Polymorphisms in the ABC drug transporter gene MDR1.

doi:10.1038/sj.tpj.6500001

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Polymorphisms in the ABC drug transporter gene MDR1.

The pharmacogenomics journal - 1 Jan 2001

Brinkmann U, Eichelbaum M

Abstract excerpt

In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and tissue levels of many drugs are influenced by controlled transport across compartmental boundaries. Major determinants in these transport processes are ATP-dependent efflux pumps such as P-glycoprotein and related proteins (eg MRPs), which can influence the bioavailability and CNS concentrations, as well as disposition of...

Topics

Animals
Biological Availability
Drug Resistance
Genes, MDR
Genetic Variation
Humans
Mice
Mice, Knockout
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 11913728
DOI: 10.1038/sj.tpj.6500001

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics