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Article

Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases.

Cancer chemotherapy and pharmacology - 1 Nov 2011

Guilhaumou Romain, Simon Nicolas, Quaranta Sylvie, Verschuur Arnauld, Lacarelle Bruno, Andre Nicolas, Solas Caroline

Abstract excerpt

PURPOSE: The interindividual variability of vincristine pharmacokinetics is quite large, but the origins of this variability are not properly understood. The aim of this study was to develop a population pharmacokinetic model of vincristine in a paediatric population treated for solid tumour disease and evaluate the impact of different ABCB1, CYP3A4 and CYP3A5 polymorphisms on the different pharmacokinetic...

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Source

Identifiers

PMID: 21404110
DOI: 10.1007/s00280-010-1541-4

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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