Article
Genetic profile of cumulative mutational damage associated with early pulmonary adenocarcinoma: bronchioloalveolar carcinoma vs. stage I invasive adenocarcinoma.
The American journal of surgical pathology - 1 Oct 2004
Sasatomi Eizaburo, Johnson Lawrence R, Aldeeb Dalal N, Lomago Deren M, Thompson James W, Swalsky Patricia A, Luketich James D, Fernando Hiran C, Finkelstein Sydney D, Yousem Samuel A
Abstract excerpt
To detect the possible genetic alterations characteristic of bronchioloalveolar carcinoma (BAC) and to study molecular genetic factors responsible for determining the biologic aggressiveness of pulmonary adenocarcinoma, comparative analysis of loss of heterozygosity (LOH) on 9 chromosomal regions was performed in 14 BACs and in 20 stage I adenocarcinomas (AD). The most frequently affected chromosome regions in...
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