Article
Topographical distributions of allelic loss in individual non-small-cell lung cancers.
The American journal of pathology - 1 Sept 2000
Yatabe Y, Konishi H, Mitsudomi T, Nakamura S, Takahashi T
Abstract excerpt
Non-small-cell carcinomas of the lung, especially adenocarcinomas, are characterized by a high degree of morphological heterogeneity. As carcinogenesis has been suggested to be a multistep process involving sequential accumulation of multiple genetic alterations, morphological heterogeneity may represent a cross-sectional view of genetic alterations within individual tumors. We therefore examined the...
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