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Article

Somatic genetic changes accompanying lung tumor development.

Genes, chromosomes & cancer - 1 Sept 2005

Foster Nicola A, Banerjee Anindo K, Xian Jian, Roberts Ian, Pezzella Francesco, Coleman Nicholas, Nicholson Andrew G, Goldstraw Peter, George Jeremy P, Rabbitts Pamela H

Abstract excerpt

Carcinomas are believed to develop by incremental steps of increasingly abnormal morphology driven by accumulating somatic genetic changes. This process is often difficult to study, as the early stages are undetectable. We used fluorescence bronchoscopy, which enhances detection of preinvasive bronchial lesions, and have obtained sequential biopsies of carcinoma in situ (CIS) from a patient with no detectable...

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Identifiers

PMID: 15937994
DOI: 10.1002/gcc.20223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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