Article
Expression of MRP and mdr1 in human gastrointestinal cancer cell lines: a correlation with resistance against doxorubicin.
Journal of surgical oncology - 1 Mar 1996
Murase M, Kodera Y, Kondo K, Sekiguchi H, Fujiwara M, Kasai Y, Akiyama S, Ito K, Takagi H
Abstract excerpt
The mRNA expression of mdr1 and MRP, each of which codes for a transport protein belonging to ATP-binding cassette superfamily and are reported to be responsible for multidrug resistance phenotype, were semi-quantified by RT-PCR in a panel of gastrointestinal cancer cell lines. Although the expression of MRP was predominant in esophageal cancer cell lines, expression of either or both of the genes was detected in...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Antibiotics, Antineoplastic
- Doxorubicin
- Drug Resistance, Neoplasm
- Gastrointestinal Neoplasms
- Gene Expression Regulation, Neoplastic
- Humans
- Multidrug Resistance-Associated Proteins
- Neoplasm Proteins
- Oncogenes