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Article

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene

18 Aug 2015

Abstract excerpt

The Journal of the National Cancer Institute published our paper entitled “Expression of a Multidrug Resistance Gene in Human Cancers” ( 1 ) 26 years ago. It was the first systematic determination of whether the energy-dependent multidrug efflux pump P-glycoprotein (P-gp), the product of the ABCB1 (MDR1) gene, was expressed in human cancers and has been cited over 1200 times. Four hundred cancers were studied,...

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PMID: 26286731
DOI: 10.1093/jnci/djv222

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