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Article

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.

Hepatology (Baltimore, Md.) - 1 Aug 2004

Toivola Diana M, Ku Nam-On, Resurreccion Evelyn Z, Nelson David R, Wright Teresa L, Omary M Bishr

Abstract excerpt

Keratin 8 and 18 (K8/18) phosphorylation plays a significant and site-specific role in regulating keratin filament organization, association with binding proteins, and modulation of cell cycle progression. Keratin hyperphosphorylation correlates with exposure to a variety of stresses in cultured cells and in mouse models of liver, pancreatic, and gallbladder injury, and it is found in association with mouse and...

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Identifiers

PMID: 15368451
DOI: 10.1002/hep.20277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.PMID 15368451Read ↗

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.Semantic proximity Read ↗

Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory‐Denk body formationSemantic proximity Read ↗

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.Semantic proximity Read ↗

A disease- and phosphorylation-related nonmechanical function for keratin 8.Semantic proximity Read ↗

Stress, Apoptosis, and Mitosis Induce Phosphorylation of Human Keratin 8 at Ser-73 in Tissues and Cultured CellsSemantic proximity Read ↗

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.Semantic proximity Read ↗

Keratins as susceptibility genes for end-stage liver disease.Semantic proximity Read ↗

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression.Semantic proximity Read ↗

Keratins turn over by ubiquitination in a phosphorylation-modulated fashion.Semantic proximity Read ↗

Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.Semantic proximity Read ↗

Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18.Semantic proximity Read ↗

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