Article
Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression.
Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2002
Ku Nam-On, Michie Sara, Resurreccion Evelyn Z, Broome Rosemary L, Omary M Bishr
Abstract excerpt
Keratin polypeptides 8 and 18 (K8/18) are the major intermediate filament proteins of simple-type epithelia. K18 Ser-33 phosphorylation regulates its binding to 14-3-3 proteins during mitosis. We studied the significance of keratin binding to 14-3-3 in transgenic mice that overexpress wild-type o...
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