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Article

Requirement of protein kinase D1 for pathological cardiac remodeling

14 Feb 2008

Abstract excerpt

The adult heart responds to biomechanical stress and neurohormonal signaling by hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a fetal gene program. Class II histone deacetylases (HDACs) suppress stress-dependent remodeling of the heart via their association with the MEF2 transcription factor, an activator of heart disease. Protein kinase D (PKD) is a stress-responsive...

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PMID: 18287012
DOI: 10.1073/pnas.0712265105

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