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Article

Aberrant RNA polymerase initiation and processivity on the genome of a herpes simplex virus 1 mutant lacking ICP27.

Journal of virology - 13 Jun 2024

Birkenheuer Claire H, Baines Joel D

Abstract excerpt

Within the first 15 minutes of infection, herpes simplex virus 1 immediate early proteins repurpose cellular RNA polymerase (Pol II) for viral transcription. An important role of the viral-infected cell protein 27 (ICP27) is to facilitate viral pre-mRNA processing and export viral mRNA to the cytoplasm. Here, we use precision nuclear run-on followed by deep sequencing (PRO-seq) to characterize transcription of a...

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Identifiers

PMID: 38780246
DOI: 10.1128/jvi.00712-24
PMCID: PMC11237563

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