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Article

Temperature-sensitive mutant in the vaccinia virus E6 protein produce virions that are transcriptionally inactive.

Virology - 10 Apr 2010

Boyd Olga, Strahl Audra L, Rodeffer Carson, Condit Richard C, Moussatche Nissin

Abstract excerpt

The vaccinia virus E6R gene encodes a late protein that is packaged into virion cores. A temperature-sensitive mutant was used to study the role of this protein in viral replicative cycle. Cts52 has a P226L missense mutation in the E6R gene, shows a two-log reduction in plaque formation, but displays normal patterns of gene expression, late protein processing and DNA replication during infection. Mutant virions...

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Identifiers

PMID: 20116822
DOI: 10.1016/j.virol.2010.01.010
PMCID: PMC2830351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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