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Article

Evidence for an essential catalytic role of the F10 protein kinase in vaccinia virus morphogenesis.

Journal of virology - 1 Jan 2004

Szajner Patricia, Weisberg Andrea S, Moss Bernard

Abstract excerpt

Temperature-sensitive mutants of vaccinia virus, with genetic changes that map to the open reading frame encoding the F10 protein kinase, exhibit a defect at an early stage of viral morphogenesis. To further study the role of the enzyme, we constructed recombinant vaccinia virus vF10V5i, which expresses inducible V5 epitope-tagged F10 and is dependent on a chemical inducer for plaque formation and replication. In...

Topics

Catalysis
Cell Line
Gene Expression Regulation, Viral
HeLa Cells
Humans
Isopropyl Thiogalactoside
Morphogenesis
Mutation
Plasmids
Protein Serine-Threonine Kinases
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vaccinia virus

Viral Proteins

Virus Assembly

Virus Replication

Source

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Identifiers

PMID: 14671107
DOI: 10.1128/jvi.78.1.257-265.2004
PMCID: PMC303407

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Evidence for an essential catalytic role of the F10 protein kinase in vaccinia virus morphogenesis.PMID 14671107Read ↗

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