Article
Enigmatic origin of the poxvirus membrane from the endoplasmic reticulum shown by 3D imaging of vaccinia virus assembly mutants.
Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2017
Weisberg Andrea S, Maruri-Avidal Liliana, Bisht Himani, Hansen Bryan T, Schwartz Cindi L, Fischer Elizabeth R, Meng Xiangzhi, Xiang Yan, Moss Bernard
Abstract excerpt
The long-standing inability to visualize connections between poxvirus membranes and cellular organelles has led to uncertainty regarding the origin of the viral membrane. Indeed, there has been speculation that viral membranes form de novo in cytoplasmic factories. Another possibility, that the connections are too short-lived to be captured by microscopy during a normal infection, motivated us to identify and...
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