Structure-Function Analysis of Two Interacting Vaccinia Proteins That Are Critical for Viral Morphogenesis: L2 and A30.5.

doi:10.1128/JVI.01577-21

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Article

Structure-Function Analysis of Two Interacting Vaccinia Proteins That Are Critical for Viral Morphogenesis: L2 and A30.5.

Journal of virology - 26 Jan 2022

Carten Juliana Debrito, Greseth Matthew, Traktman Paula

Abstract excerpt

An enduring mystery in poxvirology is the mechanism by which virion morphogenesis is accomplished. A30.5 and L2 are two small regulatory proteins that are essential for this process. Previous studies have shown that vaccinia A30.5 and L2 localize to the ER and interact during infection, but how they facilitate morphogenesis is unknown. To interrogate the relationship between A30.5 and L2, we generated inducible...

Topics

Amino Acid Motifs
Animals
Cell Line
Endoplasmic Reticulum
Genetic Complementation Test
Morphogenesis
Mutation
Protein Binding
Protein Conformation, alpha-Helical
Protein Stability
Vaccinia virus
Viral Nonstructural Proteins
Virion
Virus Assembly

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Identifiers

PMID: 34730390
DOI: 10.1128/JVI.01577-21
PMCID: PMC8791271

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