Article

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells

2020-01-06

Abstract excerpt

Protein aggregation that results in the formation of inclusions is strongly correlated with neuronal death and is a pathological hallmark common to many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington’s disease. Cells are thought to dramatically up-regulate the levels of heat shock proteins during periods of cellular stress via induction of the heat shock response (HSR). He...

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Literature Corpus work: 51b181c0-01ce-519c-a9bc-ef50eaa76f9b
DOI: 10.1101/2020.01.06.896654

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