Article
Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype.
Journal of the International Neuropsychological Society : JINS - 1 Nov 2002
Lange Kelly L, Bondi Mark W, Salmon David P, Galasko Douglas, Delis Dean C, Thomas Ronald G, Thal Leon J
Abstract excerpt
A subtle decline in episodic memory often occurs prior to the emergence of the full dementia syndrome in nondemented older adults who develop Alzheimer's disease (AD). The APOE-epsilon4 genotype may engender a more virulent form of AD that hastens this decline. To examine this possibility, we compared the rate of decline in episodic memory during the preclinical phase of AD in individuals with or without at least...
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