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Article

Apolipoprotein E variants and cognition in healthy individuals: a critical opinion.

Brain research reviews - 1 Jun 2006

Savitz Jonathan, Solms Mark, Ramesar Rajkumar

Abstract excerpt

The epsilon4 allele of apolipoprotein E (ApoE) is a well-established risk factor for late onset Alzheimer's disease (AD). This knowledge has generated interest in the role of ApoE variants in normal cognition. Varying degrees of cognitive dysfunction have been described in non-demented individuals with one or two epsilon4 alleles leading to suggestions that the gene plays a role in normal cognition or helps...

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PMID: 16378640
DOI: 10.1016/j.brainresrev.2005.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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