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Article

PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2005

Xu Xun, Bringas Pablo, Soriano Philippe, Chai Yang

Abstract excerpt

Platelet-derived growth factor receptor alpha (PDGFR-alpha) and PDGF ligands are key regulators for embryonic development. Although Pdgfralpha is spatially expressed in the cranial neural crest (CNC)-derived odontogenic mesenchyme, mice deficient for Pdgfralpha are embryonic lethal, making it impossible to investigate the functional significance of PDGF signaling in regulating the fate of CNC cells during tooth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 15543606
DOI: 10.1002/dvdy.20197

Genes

PDGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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