Article
Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.
The Journal of biological chemistry - 19 Nov 2004
Zeng Lingfang, Liao Hailing, Liu Yi, Lee Tzong-Shyuan, Zhu Minjia, Wang Xian, Stemerman Michael B, Zhu Yi, Shyy John Y-J
Abstract excerpt
ATP-binding cassette transporter A1 (ABCA1) is a pivotal regulator of cholesterol efflux from cells to apolipoproteins, whereas sterol-responsive element-binding protein 2 (SREBP2) is the key protein regulating cholesterol synthesis and uptake. We investigated the regulation of ABCA1 by SREBP2 in vascular endothelial cells (ECs). Our results showed that sterol depletion activated SREBP2 and increased its target,...
Topics
- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Adenoviridae
- Blotting, Northern
- Blotting, Western
- Cells, Cultured
- Cholesterol
- Chromatin Immunoprecipitation