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Article

Regulation and mechanisms of ATP-binding cassette transporter A1-mediated cellular cholesterol efflux.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2003

Wang Nan, Tall Alan R

Abstract excerpt

ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and HDL metabolism. ABCA1 mediates cellular cholesterol and phospholipid efflux to lipid-poor apolipoproteins, and upregulation of ABCA1 activity is antiatherogenic. ApoA-I, the major apolipoprotein component of HDL, promotes ABCA1-mediated cholesterol and phospholipid efflux, probably by directly binding to ABCA1. ABCA1...

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Source

Identifiers

PMID: 12738681
DOI: 10.1161/01.ATV.0000075912.83860.26

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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