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Article

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway.

Cell death & disease - 10 Mar 2021

Wang Gang, Chen Jiao-Jiao, Deng Wen-Yi, Ren Kun, Yin Shan-Hui, Yu Xiao-Hua

Abstract excerpt

C1q tumor necrosis factor-related protein 12 (CTRP12), a conserved paralog of adiponectin, is closely associated with cardiovascular disease. However, little is known about its role in atherogenesis. The aim of this study was to examine the influence of CTRP12 on atherosclerosis and explore the underlying mechanisms. Our results showed that lentivirus-mediated CTRP12 overexpression inhibited lipid accumulation...

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PMID: 33692340
DOI: 10.1038/s41419-021-03544-8
PMCID: PMC7947013

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